A recombinant fusion peptide produced by fermentation in E. coli, used as a skin-conditioning ingredient.
What it is
sr-Tetra (Tetra sh-Polypeptide-69 Dipeptide-78) Oligopeptide-252 is a single-chain recombinant peptide produced by fermentation in the bacterium E. coli. According to CosIng, it is a fusion of four repeats of a tetramer of sh-Polypeptide-69 followed by Dipeptide-78 and Oligopeptide-252, totalling 501 amino acids. CosIng lists it as a skin-conditioning agent.
Where it is used
Found in a small number of skin care products, such as serums and creams.
Limits of interpretation
The INCI list shows which ingredients are present, not how much of each. Above 1%, ingredients are listed in descending order of weight; below 1% the order is free.
The label does not show the concentration actually used.
Functions
- Skin conditioning – miscellaneous
- Enhancing the appearance of dry and/or damaged skin by reducing flaking and restoring suppleness.
EU regulation
This ingredient is not listed in the annexes of Regulation (EC) No 1223/2009 in the CosIng data.

