A protein-splitting enzyme of bacterial origin, listed as a keratolytic and skin-conditioning ingredient.
What it is
Subtilisin is a protease, an enzyme that splits proteins, of the serine protease type; it is named after the bacterium Bacillus subtilis, from which it was first obtained. CosIng lists it as a keratolytic and skin-conditioning ingredient.
Where it is used
Appears on the ingredient lists of a small number of products.
Limits of interpretation
The INCI list shows which ingredients are present, not how much of each. Above 1%, ingredients are listed in descending order of weight; below 1% the order is free.
The INCI name does not show the bacterial strain used or the activity of the enzyme.
Functions
- Keratolytic
- Helping to eliminate the dead cells of the stratum corneum.
- Skin conditioning
- Maintaining the skin in good condition.
EU regulation
This ingredient is not listed in the annexes of Regulation (EC) No 1223/2009 in the CosIng data.

